Fatigue reduction in the workplace
Fatigue Is the Hidden Risk You’re Not Measuring Until Now
Fatigue is one of the most expensive and overlooked risks in today’s workforce. It contributes to accidents, errors, absenteeism, burnout, healthcare costs, and turnover. Yet most organizations are still forced to manage it using self-reports, wearables, or lagging indicators such as claims data and incident reports.
Hyperion changes that
Our objective fatigue testing service makes fatigue measurable, actionable, and improvable using patented biomarker technology originally developed to solve mission-critical performance problems where failure was not an option.
Proven Where Performance Matters Most
Hyperion’s fatigue measurement technology did not originate in the wellness industry. It was developed through research supported by the U.S. Army and U.S. Air Force to help assess readiness, recovery, and performance under extreme conditions. The objective was straightforward: identify fatigue accurately, early, and objectively without relying on subjective input. From there, the technology was adopted in professional and collegiate athletics, where fatigue directly affects performance, injury risk, and long-term outcomes. Organizations have relied on Hyperion testing for years to manage performance and travel fatigue, recovery, and workload decisions across demanding seasons. Now, the same science is being deployed for employers because fatigue is no less costly in the workplace than it is on the battlefield or playing field.
Objective Fatigue Testing at Workforce Scale

Hyperion provides a three-minute, non-invasive saliva test that measures a patented molecular biomarker of fatigue. It is not a survey. It is not a sleep score. It is not a wearable estimate. It is an objective physiological measurement that is repeatable, reliable, and without bias. Saliva is collected onsite with minimal disruption and sent to the laboratory for analysis. Employees receive their results in a secure HIPAA compliant online portal. Management stakeholders receive an aggregate report identifying where fatigue is occurring and providing insight into where fatigue is highest in an organization in terms of job location and classification. For the first time, organizations can clearly see where fatigue is occurring, which populations are most at risk, how fatigue changes over time, and whether interventions are actually working.
From Measurement to Meaningful Improvement
Testing enables us to focus on employees that are highly fatigued. Every program includes education, outreach, and intervention designed to help employees understand what is driving their fatigue and how to address it using practical, realistic steps. Our intervention content is led by experts drawn from elite performance environments, including professional sports, sleep science, and behavioral health. Employees receive a clear and easy-to-understand personal fatigue report, education on the most common drivers of fatigue, and access to tailored coaching sessions, webinars, and practical resources. Leadership receives population-level reporting and analytics, identification of fatigue concentration areas and trends, and follow-up testing to quantify improvement and return on investment. After about 3 months, people are retested to evaluate progress.
Real Results and Measurable ROI
In many organizations, fatigue costs millions in lost productivity, absenteeism, and healthcare spend. Reducing fatigue can start simply enough through diet and improving the environment in which one sleeps. Small improvements may not provide a definitive cure for fatigue but they can make a difference. Encouraging participation in telemedicine and wellness resources and utilizing self-help tools available locally using a HSA account can make a difference.
AI-driven improvements in work
AI is changing how we work and how we understand complex machines like corporations. An objective and independent measure of fatigue measured through the workforce should be something you feed your AI resources routinely. While wearables may provide some insight into sleep and fatigue they can be difficult to maintain, are highly invasive and raise a host of privacy issues. Understanding your operations means obtaining solid validated data over time.
Peer reviewed publications for download
Download a publication on how fatigue biomarker can detect sleep deprivation (PDF)
Download a publication on how fatigue biomarker can detect fatigue from physical activity (PDF)
Download a publication on how fatigue biomarker predicts military training outcomes (PDF)
Download a publication on how fatigue biomarker is used to evaluate a nutritional supplement (PDF)
Download a publication expressing an opinion on fatigue biomarker (PDF)